abstract：:Conditioned pain modulation (CPM) is a phenomenon that may be tested with a dynamic quantitative sensory test that assesses the inhibitory aspect of this pain modulatory network. Although CPM has been adopted as a clinical assessment tool in recent years, the stability of the measure has not been determined over long ...

journal_title：Pain

authors： Wilson H,Carvalho B,Granot M,Landau R

更新日期：2013-12-01 00:00:00

abstract：:The molecular/genetic era has seen the discovery of a staggering number of molecules implicated in pain mechanisms [18,35,61,69,96,133,150,202,224]. This has stimulated pharmaceutical and biotechnology companies to invest billions of dollars to develop drugs that enhance or inhibit the function of many these molecules...

journal_title：Pain

authors： Reichling DB,Green PG,Levine JD

更新日期：2013-12-01 00:00:00

abstract：:Chronic pain often interferes with daily functioning, and may become a threat to an individual's sense of self. Despite the development of a recent theoretical account focussing upon the relationship between the presence of chronic pain and a person's self, research investigating this idea is limited. In the present s...

journal_title：Pain

authors： Van Ryckeghem DML,De Houwer J,Van Bockstaele B,Van Damme S,De Schryver M,Crombez G

更新日期：2013-12-01 00:00:00

abstract：:In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I-III. The main limitation has been the difficulty in defining functional populations among the...

journal_title：Pain

authors： Polgár E,Sardella TCP,Tiong SYX,Locke S,Watanabe M,Todd AJ

更新日期：2013-12-01 00:00:00

abstract：:G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous and exogenous opioids. The impact of GIRK-related genetic variation on human pain responses has received little research attention. We used a tag singl...

journal_title：Pain

authors： Bruehl S,Denton JS,Lonergan D,Koran ME,Chont M,Sobey C,Fernando S,Bush WS,Mishra P,Thornton-Wells TA

更新日期：2013-12-01 00:00:00

abstract：:After 4 millennia of more or less documented history of cannabis use, the identification of cannabinoids, and of Δ(9)-tetrahydrocannabinol in particular, occurred only during the early 1960s, and the cloning of cannabinoid CB1 and CB2 receptors, as well as the discovery of endocannabinoids and their metabolic enzymes,...

journal_title：Pain

authors： Maione S,Costa B,Di Marzo V

更新日期：2013-12-01 00:00:00

abstract：:In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and ...

journal_title：Pain

authors： Dolique T,Favereaux A,Roca-Lapirot O,Roques V,Léger C,Landry M,Nagy F

更新日期：2013-11-01 00:00:00

abstract：:Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat. However, it is not known whether such agonists are elevated in human inflammatory pain conditions. Because TRPV1 is expressed in human ...

journal_title：Pain

authors： Ruparel S,Hargreaves KM,Eskander M,Rowan S,de Almeida JFA,Roman L,Henry MA

更新日期：2013-11-01 00:00:00

abstract：:Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive and pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial to assess clinical and biochemical effects of targeted alteration in dietary n-3 and n-6 fatty acids for treatment of c...

journal_title：Pain

authors： Ramsden CE,Faurot KR,Zamora D,Suchindran CM,MacIntosh BA,Gaylord S,Ringel A,Hibbeln JR,Feldstein AE,Mori TA,Barden A,Lynch C,Coble R,Mas E,Palsson O,Barrow DA,Mann DJ

更新日期：2013-11-01 00:00:00

abstract：:Growing evidence suggests that leukocyte extravasation is initiated by the interaction of selectins with their ligands; as well as an essential role for P-selectin in the initial recruitment of inflammatory cells to sites of inflammation. In this study, P-selectin-deficient (P-sel-/-) mice were used to test the hypoth...

journal_title：Pain

authors： Liou JT,Lee CM,Lin YC,Chen CY,Liao CC,Lee HC,Day YJ

更新日期：2013-10-01 00:00:00

abstract：:Dysmenorrhea is the most prevalent gynecological disorder in women of child-bearing age. Dysmenorrhea is associated with central sensitization and functional and structural changes in the brain. Our recent brain morphometry study disclosed that dysmenorrhea is associated with trait-related abnormal gray matter (GM) ch...

journal_title：Pain

authors： Tu CH,Niddam DM,Yeh TC,Lirng JF,Cheng CM,Chou CC,Chao HT,Hsieh JC

更新日期：2013-09-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antinerve growth factor antibody in development for treatment of chronic pain. In a phase III, placebo- and active-controlled study, we investigated the efficacy and safety of tanezumab for osteoarthritis (OA) hip or knee pain. Patients (N=610) received up to 2 doses of intravenous ...

journal_title：Pain

authors： Spierings ELH,Fidelholtz J,Wolfram G,Smith MD,Brown MT,West CR

更新日期：2013-09-01 00:00:00

abstract：:It is well known that acupuncture has pain-relieving effects, but the contribution of specific and especially nonspecific factors to acupuncture analgesia is less clear. One hundred one patients who developed pain of ≥ 3 on a visual analog scale (VAS, 0 to 10) after third molar surgery were randomized to receive activ...

journal_title：Pain

authors： Vase L,Baram S,Takakura N,Yajima H,Takayama M,Kaptchuk TJ,Schou S,Jensen TS,Zachariae R,Svensson P

更新日期：2013-09-01 00:00:00

abstract：:Intraoral somatosensory sensitivity in patients with atypical odontalgia (AO) has not been investigated systematically according to the most recent guidelines. The aims of this study were to examine intraoral somatosensory disturbances in AO patients using healthy subjects as reference, and to evaluate the percent agr...

journal_title：Pain

authors： Baad-Hansen L,Pigg M,Ivanovic SE,Faris H,List T,Drangsholt M,Svensson P

更新日期：2013-08-01 00:00:00

abstract：:No research to date has descriptively catalogued what parents of healthy infants are naturalistically doing to manage their infant's pain over immunization appointments during the first year of life. This knowledge, in conjunction with an understanding of the relationships different parental techniques have with infan...

journal_title：Pain

authors： Lisi D,Campbell L,Pillai Riddell R,Garfield H,Greenberg S

更新日期：2013-08-01 00:00:00

abstract：:Pain is a frequently observed non-motor symptom of patients with Parkinson's disease. In some patients, Parkinson's-related pain responds to dopaminergic treatment. In the present study, we aimed to elucidate whether subthalamic deep brain stimulation has a similar beneficial effect on pain in Parkinson's disease, and...

journal_title：Pain

authors： Sürücü O,Baumann-Vogel H,Uhl M,Imbach LL,Baumann CR

更新日期：2013-08-01 00:00:00

abstract：:The perception of pain is determined by a combination of genetic, neurobiological, cultural, and emotional factors. Recent studies have demonstrated an association between specific genotypes and pain perception. Particular focus has been given to the triallelic polymorphism in the promoter region of the serotonin tran...

journal_title：Pain

authors： Horjales-Araujo E,Demontis D,Lund EK,Vase L,Finnerup NB,Børglum AD,Jensen TS,Svensson P

更新日期：2013-08-01 00:00:00

abstract：:Central poststroke pain (CPSP) is one of the most refractory chronic pain syndromes. Repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex has been demonstrated to provide moderate pain relief for CPSP. However, the mechanism underlying the pain relief remains unclear. The objective of this s...

journal_title：Pain

authors： Hosomi K,Kishima H,Oshino S,Hirata M,Tani N,Maruo T,Yorifuji S,Yoshimine T,Saitoh Y

更新日期：2013-08-01 00:00:00

abstract：:Tanezumab is a humanized monoclonal antibody that specifically inhibits nerve growth factor as a treatment for chronic pain. This phase IIB study investigated the efficacy and safety of tanezumab for chronic low back pain vs placebo and naproxen. Patients (N=1347) received intravenous tanezumab (5, 10, or 20mg every 8...

journal_title：Pain

authors： Kivitz AJ,Gimbel JS,Bramson C,Nemeth MA,Keller DS,Brown MT,West CR,Verburg KM

更新日期：2013-07-01 00:00:00

abstract：:To characterize the contribution of interleukin-6 (IL-6) to spinal cord injury pain (SCIP), we employed a clinically relevant rat contusion model of SCIP. Using Western blots, we measured IL-6 levels in lumbar segments (L1-L5), at the lesion site (T10), and in the corresponding lumbar and thoracic dorsal root ganglia ...

journal_title：Pain

authors： Guptarak J,Wanchoo S,Durham-Lee J,Wu Y,Zivadinovic D,Paulucci-Holthauzen A,Nesic O

更新日期：2013-07-01 00:00:00

abstract：:The present study evaluated the efficacy of a clinician-guided Internet-delivered cognitive behaviour therapy (iCBT) program, the Pain Course, to reduce disability, anxiety, and depression associated with chronic pain. Sixty-three adults with chronic pain were randomised to either a Treatment Group or waitlist Control...

journal_title：Pain

authors： Dear BF,Titov N,Perry KN,Johnston L,Wootton BM,Terides MD,Rapee RM,Hudson JL

更新日期：2013-06-01 00:00:00

abstract：:microRNAs (miRNAs) are small noncoding RNAs that have been linked to a number of disease-related signal transduction pathways. Several studies indicate that they are also involved in nociception. It is not clear, however, which miRNAs are important and which genes are modulated by miRNA-associated mechanisms. This stu...

journal_title：Pain

authors： Kynast KL,Russe OQ,Möser CV,Geisslinger G,Niederberger E

更新日期：2013-03-01 00:00:00

abstract：:Morphine is widely used to treat severe pain in neonatal intensive care unit patients. Animal studies suggest adverse long-term side effects of neonatal morphine, but a follow-up study of 5-year-old children who participated in a morphine-placebo controlled trial as newborns found no such effects on the child's genera...

journal_title：Pain

authors： de Graaf J,van Lingen RA,Valkenburg AJ,Weisglas-Kuperus N,Jebbink LG,Wijnberg-Williams B,Anand KJS,Tibboel D,van Dijk M

更新日期：2013-03-01 00:00:00

abstract：:Recent evidence indicates that pain-related fear can be acquired through associative learning. In the clinic, however, spreading of fear and avoidance is observed beyond movements/activities that were associated with pain during the original pain episode. One mechanism accounting for this spreading of fear is stimulus...

journal_title：Pain

authors： Meulders A,Vlaeyen JWS

更新日期：2013-02-01 00:00:00

abstract：:High-quality information on the potential benefit and harm of a drug is required for patients and clinicians to make informed treatment decisions and to enable cost-effectiveness modeling to be undertaken. This systematic review describes the collection and reporting of adverse event data as presented in published cli...

journal_title：Pain

authors： Cornelius VR,Sauzet O,Williams JE,Ayis S,Farquhar-Smith P,Ross JR,Branford RA,Peacock JL

更新日期：2013-02-01 00:00:00

abstract：:Human unmyelinated (C) tactile afferents signal the pleasantness of gentle skin stroking on hairy (nonglabrous) skin. After neuronal injury, that same type of touch can elicit unpleasant sensations: tactile allodynia. The prevailing pathophysiological explanation is a spinal cord sensitization, triggered by nerve inju...

journal_title：Pain

authors： Liljencrantz J,Björnsdotter M,Morrison I,Bergstrand S,Ceko M,Seminowicz DA,Cole J,Bushnell CM,Olausson H

更新日期：2013-02-01 00:00:00

abstract：:Peripheral nerve injury provokes heightened excitability of primary sensory afferents including nociceptors, and elicits ectopic activity in lesioned and neighboring intact nerve fibers. The major transmitter released by sensory afferents in the superficial dorsal horn of the spinal cord is glutamate. Glutamate is cri...

journal_title：Pain

authors： Inquimbert P,Bartels K,Babaniyi OB,Barrett LB,Tegeder I,Scholz J

更新日期：2012-12-01 00:00:00

abstract：:A fundamental question for placebo research is whether such responses are a predisposition, quantifiable by brain characteristics. We examine this issue in chronic back pain (CBP) patients who participated in a double-blind brain imaging (functional magnetic resonance imaging) clinical trial. We recently reported that...

journal_title：Pain

authors： Hashmi JA,Baria AT,Baliki MN,Huang L,Schnitzer TJ,Apkarian VA

更新日期：2012-12-01 00:00:00

abstract：:Chronic pain is currently considered a public health problem with high costs to the individual and society. To improve prevention and treatment of chronic pain, epidemiologic studies are mandatory for assessing chronic pain. The aims of this study were to estimate the prevalence of chronic pain in the adult Danish pop...

journal_title：Pain

authors： Kurita GP,Sjøgren P,Juel K,Højsted J,Ekholm O

更新日期：2012-12-01 00:00:00

abstract：:Slow-release strong opioids (SRSO) are indicated in patients with severe chronic pain. Side effects, lack of efficacy and risk of dependency limit their use in clinical practice. The aim of this study was to explore prescription patterns of SRSO in Swedish real-world data on patients with a diagnosis related to chroni...

journal_title：Pain

authors： Gustavsson A,Bjorkman J,Ljungcrantz C,Rhodin A,Rivano-Fischer M,Sjolund FK,Mannheimer C

更新日期：2012-12-01 00:00:00

abstract：:The objective of this study was to examine which factors during pregnancy and postpartum predict pelvic girdle pain (PGP) at 12 weeks postpartum among working women. A total of 548 Dutch pregnant employees were recruited in 15 companies, mainly health care, child care, and supermarkets. The definition of PGP was any p...

journal_title：Pain

authors： Stomp-van den Berg SGM,Hendriksen IJM,Bruinvels DJ,Twisk JWR,van Mechelen W,van Poppel MNM

更新日期：2012-12-01 00:00:00

abstract：:In this study, construct validity of 2 pain behaviour observation measurement instruments for young children aged 1 to 56 months (mean age was 20 months) with burns is assessed by using Rasch analysis. The Rasch model, wherein data should meet the model expectations, assumes that an instrument measures one unidimensio...

journal_title：Pain

authors： de Jong AEE,Tuinebreijer WE,Bremer M,van Komen R,Middelkoop E,van Loey N

更新日期：2012-11-01 00:00:00

abstract：:Back pain is a leading cause of disability. Previous research suggests that modifiable risk factors influence recovery from back pain, and practice guidelines recommend integrating such factors within primary care management. Toward this goal, a brief, multidimensional questionnaire, the STarT Back Tool, was designed ...

journal_title：Pain

authors： Wideman TH,Hill JC,Main CJ,Lewis M,Sullivan MJL,Hay EM

更新日期：2012-11-01 00:00:00

abstract：:This study determined preoperative predictors of movement and resting pain following total knee replacement (TKR). We hypothesized that younger patients with higher preoperative pain intensity, pain sensitivity, trait anxiety, pain catastrophizing, and depression would be more likely to experience higher postoperative...

journal_title：Pain

authors： Rakel BA,Blodgett NP,Zimmerman BM,Logsden-Sackett N,Clark C,Noiseux N,Callaghan J,Herr K,Geasland K,Yang X,Sluka KA

更新日期：2012-11-01 00:00:00

abstract：:Chronic pain is frequently accompanied by a deterioration of emotional behavior and cognitive function. A small number of studies in humans concluded that pain-associated negative affect is more pronounced when pain is localized in the left side of the body. It has been suggested that such side bias results from corti...

journal_title：Pain

authors： Leite-Almeida H,Cerqueira JJ,Wei H,Ribeiro-Costa N,Anjos-Martins H,Sousa N,Pertovaara A,Almeida A

更新日期：2012-11-01 00:00:00

abstract：:Polyneuropathy can be linked to chronic pain but also to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify pain-specific changes. Eleven polyneuropathy patients with persistent spontaneous pain and 8 polyneuropathy patients without spontaneou...

journal_title：Pain

authors： Kleggetveit IP,Namer B,Schmidt R,Helås T,Rückel M,Ørstavik K,Schmelz M,Jørum E

更新日期：2012-10-01 00:00:00

abstract：:Cannabinoids are emerging as potential options for neuropathic pain treatment. This study evaluated an oral cannabinoid, nabilone, in the treatment of refractory human diabetic peripheral neuropathic pain (DPN). We performed a single-center, randomized, double-blind, placebo-controlled, flexible-dose study with an enr...

journal_title：Pain

authors： Toth C,Mawani S,Brady S,Chan C,Liu C,Mehina E,Garven A,Bestard J,Korngut L

更新日期：2012-10-01 00:00:00

abstract：:A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal proteins. Recent evidence has demonstrated a correlation between the expression of some of these molecular markers and transmission of signals related to distinct ...

journal_title：Pain

authors： Shields SD,Ahn HS,Yang Y,Han C,Seal RP,Wood JN,Waxman SG,Dib-Hajj SD

更新日期：2012-10-01 00:00:00

abstract：:Neurotrophin-3 (NT-3) is a target-derived neurotrophic factor that regulates sensory neuronal survival and growth. Here we report that NT-3 plays a critical permissive role in cutaneous sensory nerve sprouting that contributes to pain and sensitivity following skin wounding in young animals. Sensory terminal sprouting...

journal_title：Pain

authors： Beggs S,Alvares D,Moss A,Currie G,Middleton J,Salter MW,Fitzgerald M

更新日期：2012-10-01 00:00:00

abstract：:Although pediatric functional abdominal pain (FAP) has been linked to abdominal pain later in life, childhood predictors of long-term outcomes have not been identified. This study evaluated whether distinct FAP profiles based on patterns of pain and adaptation in childhood could be identified and whether these profile...

journal_title：Pain

authors： Walker LS,Sherman AL,Bruehl S,Garber J,Smith CA

更新日期：2012-09-01 00:00:00